AI Article Synopsis
- Cholangiocarcinoma (CCA) refers to tumors found in the bile ducts, with a low five-year survival rate of under 20% and limited progress in targeted therapies compared to the standard treatment of cisplatin and gemcitabine.
- Recent advancements in next-generation sequencing have uncovered significant genetic diversity among different CCA subtypes, which could influence how future treatment trials are organized.
- This review summarizes the latest clinical management practices for CCA, highlighting findings from recent genomic studies and variations among CCA subtypes.
Article Abstract
The term cholangiocarcinoma (CCA) comprises neoplasms of the intrahepatic, perihilar, and distal bile duct. Five-year survival rates of patients with CCA are below 20 %, and no targeted therapy could prove a benefit in comparison to the standard treatment of cisplatinum and gemcitabine. In recent years, next generation sequencing studies revealed a profound genomic heterogeneity of CCA subtypes potentially affecting the design of future therapy trials. This review provides a concise update on current clinical management of CCA including data of recent genomic studies and differences between CCA subtypes.
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| http://dx.doi.org/10.1055/s-0043-102581 | DOI Listing |
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