We explored conditions under which being in the loop may be an undesirable experience. We tested whether information valence moderates the effects of being in versus out of the loop in four studies. In a pilot study, participants imagined positive and negative events and indicated the degree to which they would like to know this information. In Study 1, participants imagined being in or out of the loop on positive or negative information and indicated how they would feel. In Study 2, participants relived an actual experience when they were in or out of the loop on positive or negative information. In Study 3, participants were in or out of the loop on positive or negative information needed for an upcoming task. These studies provide evidence that being in the loop on negative information can be an unenjoyable experience, threatening fundamental needs and increasing negative affect.
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http://dx.doi.org/10.1080/00224545.2017.1314247 | DOI Listing |
MAbs
January 2019
a Division of Biotherapeutics , National Institute for Biological Standards and Control (NIBSC), South Mimms , Potters Bar, Hertfordshire , UK.
Due to the increase in the number of infliximab products, the need for global harmonization of the bioactivity of this monoclonal antibody was recognized by the World Health Organization (WHO). In response, the National Institute for Biological Standards and Control (NIBSC) developed the first international standard (IS) for infliximab, which targets tumour necrosis factor (TNF). Each ampoule is assigned values of 500 IU of TNF neutralizing activity and 500 IU of binding activity.
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