An enantioselective Ni-catalyzed cross-coupling of N-hydroxyphthalimide esters with vinyl bromides is reported. The reaction proceeds under mild conditions and uses tetrakis(N,N-dimethylamino)ethylene as a terminal organic reductant. Good functional group tolerance is demonstrated, with over 20 examples of reactions that proceed with >90% ee.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868419 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.7b00793 | DOI Listing |
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