AI Article Synopsis
- Atherosclerosis is a long-lasting inflammatory disease where the differentiation and activation of monocytes and macrophages play crucial roles in its development.
- The regulatory mechanisms controlling how monocytes and macrophages function are not fully understood, prompting research into epigenetic factors.
- Epigenetic mechanisms are increasingly recognized as significant in influencing monocyte and macrophage behavior, offering potential new strategies for identifying targets or biomarkers for atherosclerosis.
Article Abstract
Atherosclerosis is a chronic inflammatory disease. Recently, a growing body of evidence emphasizes that the monocyte and macrophage differentiation and activation are key processes in the development of atherosclerosis. However, the regulatory mechanism that manipulates the function of monocyte and macrophage is still unclear. Recent years, epigenetic mechanisms have received a wide attention and bring us a new field of vision. More and more evidence shows that epigenetics weighs heavily in atherosclerosis by regulating the function and differentiation states of monocyte and macrophage. In this review, we illuminate the epigenetic regulation mechanisms in monocyte and macrophage and their contributions to inflammatory processes of atherosclerosis to provide new thoughts and find novel targets or biomarkers for atherosclerosis.
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| http://dx.doi.org/10.1111/1755-5922.12262 | DOI Listing |
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