Meta-C-H functionalization of benzylamines has been developed using a Pd /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512280 | PMC |
| http://dx.doi.org/10.1002/anie.201701803 | DOI Listing |
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