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Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from COVID-19.
Reprod Med Biol
January 2025
Division of Urology, Department of Organs Therapeutics Kobe University Graduate School of Medicine Kobe Japan.
Background: As the COVID-19 pandemic nears resolution in 2024, the mechanisms by which SARS-CoV-2 and other viral infections induce spermatogenic dysfunction remain poorly understood. This review examines the mechanisms by which viral infections, particularly COVID-19, disrupt spermatogenesis and highlights the implications for male reproductive health. While reports suggest that spermatogenic dysfunction caused by COVID-19 is mild and transient, these findings may have broader applications in understanding and treating spermatogenic dysfunction caused by future viral infections.
View Article and Find Full Text PDFProtein handling in kidney tubules.
Nat Rev Nephrol
January 2025
Institute of Anatomy, University of Zurich, Zurich, Switzerland.
The kidney proximal tubule reabsorbs and degrades filtered plasma proteins to reclaim valuable nutrients and maintain body homeostasis. Defects in this process result in proteinuria, one of the most frequently used biomarkers of kidney disease. Filtered proteins enter proximal tubules via receptor-mediated endocytosis and are processed within a highly developed apical endo-lysosomal system (ELS).
View Article and Find Full Text PDFCost-effective and simple flow cytometry quantification of receptor-mediated autophagy using fluorescent tagging.
FEBS Open Bio
December 2024
School of Medicine, University of Split, Croatia.
Mitophagy, a selective clearance of damaged or superfluous mitochondria via autophagy machinery and lysosomal degradation, is an evolutionarily conserved process essential for various physiological functions, including cellular differentiation and immune responses. Defects in mitophagy are implicated in numerous human diseases, such as neurodegenerative disorders, cancer, and metabolic conditions. Despite significant advancements in mitophagy research over recent decades, novel and robust methodologies are necessary to elucidate its molecular mechanisms comprehensively.
View Article and Find Full Text PDFNatural infection of hybrid sturgeon (♀×♂) with and white sturgeon iridovirus: pathological and transcriptomic analyses.
Front Immunol
December 2024
Fisheries Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, Sichuan, China.
Introduction: In August 2023, hybrid sturgeons () cultured in Sichuan, China, showed infectious disease symptoms, including ulcers, liver and spleen nodules, and high mortality rates.
Methods: Pathogenic bacteria were isolated from the liver of diseased sturgeons and analyzed for their phenotypic and molecular traits. Furthermore, iridovirus-specific TaqMan real-time PCR (RT-PCR) analyses were conducted.
Inhibition of histamine receptor 3 alleviates sevoflurane-induced hypomyelination and neurobehavioral deficits.
Exp Neurol
December 2024
Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China. Electronic address:
Background: Inhalational anesthetic sevoflurane can cause myelination damage in developing brain. This study examines the effects of histamine receptor 3 (H3) antagonist thioperamide on sevoflurane-induced hypomyelination and neurobehavioral deficits.
Methods: Neonatal C57BL/6 mice were exposed to sevoflurane for consecutive three days and treated with H3 receptor antagonist thioperamide.
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