AI Article Synopsis
- The study examined the effects of methylphenidate (MPH) on anxiety and depression in 12 patients aged 8-18 diagnosed with Asperger syndrome (AS) and ADHD over 12 weeks.
- Significant reductions in ADHD symptoms and depression were observed, while general anxiety symptoms remained unchanged, though school-related anxiety showed improvement.
- The findings suggest that MPH treatment is safe and effective for reducing depression and school-related anxiety in this patient group.
Article Abstract
The objective of this study was to assess the response of anxiety and depression symptoms to methylphenidate (MPH) treatment in patients with Asperger syndrome (AS) combined with attention deficit/hyperactivity disorder (ADHD). A group of 12 patients with AS/ADHD, aged 8-18 years, received 12 weeks of MPH treatment. The severities of ADHD, anxiety, and depression symptoms were assessed by means of the ADHD Rating Scale (ADHD-RS), Screen for Child Anxiety Related Emotional Disorders, and the Children's Depression Inventory. The severity of ADHD and depression symptoms was reduced significantly (P<0.0003 and P=0.046, respectively). No improvement in total anxiety symptoms was found, but a significant reduction was obtained in the school-related subscale of the Screen for Child Anxiety Related Emotional Disorders (P=0.0054). A positive correlation was found between the reductions in ADHD-RS and Children's Depression Inventory scores (r=0.59, P=0.039). MPH treatment may be safe, tolerable, and effective in alleviating depression and school-related anxiety symptoms in patients with AS and ADHD.
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| http://dx.doi.org/10.1097/YIC.0000000000000175 | DOI Listing |
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