We examined the effect of 1α-hydroxyvitamin D [1α(OH)D] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D may have antidepressant-like activity.
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| http://dx.doi.org/10.3177/jnsv.63.81 | DOI Listing |
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