This study examined the additive effects of social support and negative interactions in various relationship domains and the cross-domain buffering effects of social support on the detrimental impact of negative interactions on mental health among older adults in Japan. Data were obtained from a survey of residents of 30 municipalities in the Tokyo metropolitan area ( N = 1,592). The results indicated that family members living together may share ambivalent social ties, anchored in positive sentiments and serving as sources of support but where criticism and excessive demands may occur. We found that negative interactions had a more potent additive effect on mental health. Moreover, the interaction effects of negative interactions with family and social support from other relatives suggested reverse buffering. Our findings suggest that interventions might be more necessary to cope with the negative social exchanges of close kin relationships among the elderly Japanese.
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http://dx.doi.org/10.1177/0164027517701446 | DOI Listing |
Front Immunol
January 2025
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer, and despite low incidence rates, it remains the sixth leading cause of cancer related deaths worldwide. Immunotherapy, which aims to enhance the immune system's ability to recognize and eliminate cancer cells, has emerged as a promising approach in the battle against PDAC. PARP7, a mono-ADP-ribosyltransferase, is a negative regulator of the type I interferon (IFN-I) pathway and has been reported to reduce anti-tumour immunity.
View Article and Find Full Text PDFFront Immunol
January 2025
Xin'an Medicine Research Center, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, China.
Background: is a differentially expressed gene (DEG) between M1 and M2 macrophages. This study explained why it causes opposite effects in different circumstances.
Methods: Gene expression profiles of various cell subsets were compared by mining a public database.
Cytotechnology
April 2025
Department of Child Health, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Wuhan, 430070 China.
Unlabelled: Inflammatory bowel disease (IBD), a chronic gastrointestinal disorder, often emerges during childhood and poses significant challenges due to its adverse effects on growth, development, and psychosocial well-being. Circular RNAs (circRNAs) have been implicated in the pathogenesis of diverse diseases. However, the specific biological role and mechanisms of circRNA OMA1 in children with IBD remain largely unexplored.
View Article and Find Full Text PDFFront Sports Act Living
January 2025
Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Introduction: Psychological abuse continues to be the most frequently reported type of maltreatment among athletes leading to negative mental health such as low mood and self-esteem, increased anxiety, self-harm, and eating disorders. Preliminary evidence suggests athlete satisfaction can influence the perceived outcomes associated with psychological abuse. Despite its negative impacts on athletes, psychological abuse continues to be justified as a tool to enhance athletic performance.
View Article and Find Full Text PDFJ Asthma Allergy
January 2025
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Background: The role of memory B cells and their subgroups in allergic rhinitis (AR) and allergen immunotherapy (AIT) remains unclear. This study aimed to investigate the characteristics of memory B cells in the circulation of patients with AR and those undergoing AIT, as well as their clinical significance.
Methods: This study involved a cohort comprising 32 healthy control subjects, 39 individuals diagnosed with AR, and 31 AR patients who had received AIT for over one year.
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