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FDA-Approved Oligonucleotide Therapies in 2017. | LitMetric

FDA-Approved Oligonucleotide Therapies in 2017.

Mol Ther

Department of Medical Oncology and Experimental Therapeutics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

Published: May 2017

Oligonucleotides (oligos) have been under clinical development for approximately the past 30 years, beginning with antisense oligonucleotides (ASOs) and apatmers and followed about 15 years ago by siRNAs. During that lengthy period of time, numerous clinical trials have been performed and thousands of trial participants accrued onto studies. Of all the molecules evaluated as of January 2017, the regulatory authorities assessed that six provided clear clinical benefit in rigorously controlled trials. The story of these six is given in this review.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417833PMC
http://dx.doi.org/10.1016/j.ymthe.2017.03.023DOI Listing

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