AI Article Synopsis
- The study investigates the effects and side effects of Ra on two age groups of patients with castrate-resistant prostate cancer.
- Both age groups exhibited similar clinical benefits, but younger patients showed a higher rate of grade 3 anemia and had more prior treatments with docetaxel.
- Overall, Ra was found to be well-tolerated, with the higher anemia rates in the younger group potentially reflecting stricter patient selection criteria in older patients.
Article Abstract
Purpose: To examine the clinical benefits and toxicities of Ra in 2 different age groups of patients with castrate-resistant prostate cancer.
Methods And Materials: This was a retrospective study of patients treated with Ra in 2 tertiary centers. Patients were divided into 2 different groups based on their age (≥72 years old and <72 years old). Treatment toxicities were graded according to Common Terminology Criteria for Adverse Events version 4.0. Comparison of characteristics and outcome was carried out with the Mann-Whitney test and analysis of overall survival with the log-rank test.
Results: In all, 129 patients were treated during the study period. Clinical benefit was similar in both groups. However, a statistically significant higher proportion of patients in the younger group had previously been treated with docetaxel. There was a higher rate of grade 3 anemia in younger patients.
Conclusions: In line with other studies, Ra was well tolerated with minimum toxicities. The significantly higher rate of grade 3 anemia in younger patients may be due to more cautious patient selection in the elderly population.
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| http://dx.doi.org/10.1016/j.ijrobp.2017.01.208 | DOI Listing |
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