AI Article Synopsis
- The study focuses on creating new composite films using polyvinyl alcohol and carboxymethyl tamarind gum, showing successful formation through microscopic analysis.
- FTIR spectroscopy indicates hydrogen bonding among the film components, which varies with composition, particularly enhancing at a specific mix that also affects polymer relaxation times.
- Films containing ciprofloxacin demonstrated strong antibacterial effects against E. coli and promoted better cell growth in skin cells, suggesting potential applications in skin tissue engineering and drug delivery.
Article Abstract
The present study delineates the synthesis of novel composite films using polyvinyl alcohol and carboxymethyl tamarind gum. The microscopic study results confirmed the formation of composite matrices. FTIR spectroscopy suggested the occurrence of hydrogen-bonding amongst the components of the films. The extent of hydrogen bonding was composition-dependent which reached a critical higher limit at a particular composition. At the critical composition, the instantaneous and the intermediate polymer relaxation time were longer. All the films were found to be viscoelastic in nature. The melting endotherm was also highest for the composition described above. Ciprofloxacin loaded films showed excellent antimicrobial property against E. coli, suggesting that the drug was released in its active form. Cell proliferation study using human keratinocytes suggested better cell proliferation in the CMT containing films as compared to the control (PVA only) film. In gist, the developed films can be explored for skin tissue engineering and drug delivery applications.
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| http://dx.doi.org/10.1016/j.carbpol.2017.02.026 | DOI Listing |
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