AI Article Synopsis
- * Tissue engineering offers a potential alternative by creating functional substitutes for damaged musculoskeletal tissues, but it requires a robust vascular network to ensure nutrient and oxygen supply after implantation.
- * Recent advancements in therapeutic nanomaterials show promise in delivering growth factors and other resources to support the creation of vascularized scaffolds, and the text discusses current efforts and future directions for improving vascularization and tissue function in treatments.
Article Abstract
Current treatments for musculoskeletal disease and injury are restricted with the usage of autografts and allografts. Tissue engineering that applies the principles of biology and engineering to develop functional substitutes has potential promise of therapeutic regeneration for musculoskeletal tissues. However, engineering sizable tissues needs a vascular network to supply cells with nutrients, oxygen and signals after implantation. For this purpose, recent developments on therapeutic nanomaterials have been explored in delivering different vessel-inductive growth factors, small biomolecules and ions for scalable engineering into vascularizable scaffolds. Here, we provide an overview on the current efforts, and propose future perspectives for precise regulation on vascularization processes and musculoskeletal tissue functionality.
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| http://dx.doi.org/10.1016/j.drudis.2017.03.010 | DOI Listing |
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