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| http://dx.doi.org/10.1097/FPC.0000000000000279 | DOI Listing |
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High-coverage whole-genome sequencing of a Jakun individual from the "Orang Asli" Proto-Malay subtribe from Peninsular Malaysia.
Hum Genome Var
January 2025
Faculty of Medicine and Health Sciences, UCSI University, Negeri Sembilan, Federal Territory of Kuala Lumpur, Malaysia.
Jakun, a Proto-Malay subtribe from Peninsular Malaysia, is believed to have inhabited the Malay Archipelago during the period of agricultural expansion approximately 4 thousand years ago (kya). However, their genetic structure and population history remain inconclusive. In this study, we report the genome structure of a Jakun female, based on whole-genome sequencing, which yielded an average coverage of 35.
View Article and Find Full Text PDFExploring the Effect of Gomisin A on Non-Small Cell Lung Cancer With Network Pharmacology, Molecular Docking, In Vitro and In Vivo Assays.
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November 2024
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Gomisin A is an active ingredient of Schisandra chinensis. Pre-clinical studies suggest Gomisin A has good anti-cancer activities against a variety of cancers, but its mechanism of action in non-small cell lung cancer (NSCLC) is unclear. This study aims to explore the potential mechanism of Gomisin A in treating NSCLC.
View Article and Find Full Text PDFPharmVar GeneFocus: CYP4F2.
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October 2024
Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Research Institute (CMRI), Kansas City, Missouri, USA.
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This GeneFocus provides a comprehensive overview and summary of CYP4F2 genetic variation including the characterization of 14 novel star alleles, CYP4F2*4 through *17.
View Article and Find Full Text PDF[Mechanism of bulleyaconitine A in inhibiting bone destruction of rheumatoid arthritis via Src/PI3K/Akt signaling pathway].
Zhongguo Zhong Yao Za Zhi
March 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Article Synopsis
- The study investigates how bulleyaconitine A affects bone destruction in rheumatoid arthritis through the Src/PI3K/Akt signaling pathway.
- Researchers identified key RA targets and bulleyaconitine A's potential targets using various databases, and conducted analyses to understand their interactions and functions.
- Experimental results show that bulleyaconitine A inhibited the expression of genes linked to osteoclast differentiation, indicating its potential as a treatment for RA-related bone damage.
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