The effects of a long-term administration of melatonin on the zona glomerulosa were investigated both in "normal" rats and in animals in which the hypothalamo-hypophyseal-adrenal axis and the renin-angiotensin system had been pharmacologically interrupted. Melatonin caused a notable hypertrophy of zona glomerulosa cells and a significant rise in the plasma concentration of aldosterone in both groups of rats. These findings indicate that melatonin exerts in vivo a strong direct stimulatory action on the growth and steroidogenic capacity of the rat zona glomerulosa.

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0029-1210722DOI Listing

Publication Analysis

Top Keywords

zona glomerulosa
16
morphometric study
4
study effects
4
melatonin
4
effects melatonin
4
melatonin rat
4
rat adrenal
4
zona
4
adrenal zona
4
glomerulosa
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!