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Effects of data transformation and model selection on feature importance in microbiome classification data.
Microbiome
January 2025
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Background: Accurate classification of host phenotypes from microbiome data is crucial for advancing microbiome-based therapies, with machine learning offering effective solutions. However, the complexity of the gut microbiome, data sparsity, compositionality, and population-specificity present significant challenges. Microbiome data transformations can alleviate some of the aforementioned challenges, but their usage in machine learning tasks has largely been unexplored.
View Article and Find Full Text PDFDoes the Coronary Artery Bypass Grafting Impact the Survival of Men and Women Equally Compared to General Population? Results from KROK Registry and Polish Central Statistical Office.
J Clin Med
December 2024
Department of Cardiac Surgery, Vascular and Endovascular Surgery, and Heart Transplantology, Silesian Centre for Heart Diseases, Medical University of Silesia, 40-055 Zabrze, Poland.
The aim of this study was to evaluate the impact of coronary bypass surgery (CABG) on long-term mortality, comparing survival rates to those of the general population in Poland. The study was based on the Polish National Register of Cardiothoracic Surgical Procedures (KROK). Between January 2009 and December 2019, 133,973 patients underwent CABG.
View Article and Find Full Text PDFA rapid parallel increase in the incidence and mortality of head and neck cancer among the Polish elderly over the last two decades and upward trends until 2035.
Otolaryngol Pol
December 2024
Department of Otolaryngology, Regional Specialist Hospital Wroclaw, Research & Development Centre, Wroclaw, Poland, Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
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- The study reveals a significant rise in head and neck cancer (HNC) cases and deaths among the elderly in Poland from 1999 to 2021, particularly in those aged 80 and older.
- The research analyzed data from the Polish National Cancer Register and applied statistical methods to assess trends and correlations in morbidity and mortality across different age groups.
- The results indicate an urgent need for specialized cancer care strategies to improve treatment outcomes and quality of life for elderly patients, especially for the 80+ demographic.
Performance of EuroSCORE II in Octogenarians Undergoing Coronary Artery Surgery (from the KROK Registry).
J Clin Med
November 2024
Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Centre for Heart Diseases, Medical University of Silesia, 41-800 Zabrze, Poland.
Octogenarians constitute the fastest-growing segment within contemporary cardiac surgery, yet precise risk assessment in this age group remains challenging. This study aimed to evaluate EuroSCORE II reliability in octogenarians undergoing isolated coronary surgery and to create an adjustment formula if necessary. All octogenarians who had isolated coronary surgery in Poland from January 2012 to December 2023, recorded in the Polish National Registry of Cardiac Surgical Procedures (KROK registry), were retrospectively assessed.
View Article and Find Full Text PDFDiscrepancies between pre-specified and reported primary outcomes: A cross-sectional analysis of randomized controlled trials in gastroenterology and hepatology journals.
PLoS One
November 2024
Editorial Office, AME Publishing Company, Hong Kong, China.
Background: Previous research has raised concerns regarding inconsistencies between reported and pre-specified outcomes in randomized controlled trials (RCTs) across various biomedical disciplines. However, studies examining whether similar discrepancies exist in RCTs focusing on gastrointestinal and liver diseases are limited. This study aimed to assess the extent of discrepancies between registered and published primary outcomes in RCTs featured in journals specializing in gastroenterology and hepatology.
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