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Evaluation of Quinoline-Related Carboxylic Acid Derivatives as Prospective Differentially Antiproliferative, Antioxidative, and Anti-Inflammatory Agents.
Chem Biol Drug Des
October 2024
Al-Balqa Applied University, Salt, Jordan.
The higher prevalence of cancer and the unmet need for antioxidant/anti-inflammatory chemotherapeutic compounds with little side effect are of utmost importance. In addition, the increased likelihood of failure in clinical trials along with increasing development costs may have diminished the range of choices among newer drugs for clinical use. This has dictated the necessity to seek out novel medications by repurposing as it needs less time, effort, and resources to explore new uses of a current or unsuccessful medication.
View Article and Find Full Text PDFFurosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review.
Pediatr Int
September 2024
Department of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Background: Although furosemide is used during cyclooxygenase (COX) inhibitor therapy for patent ductus arteriosus (PDA), there are concerns regarding increased ductal closure failure and acute renal failure (ARF). This systematic review explores the effects of furosemide during COX inhibitor therapy.
Methods: We searched MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi databases for randomized clinical trials that assessed furosemide during COX inhibitor therapy for PDA in preterm infants.
An Unusual Presentation of Failure to Thrive in a Toddler: Bartter Syndrome.
Cureus
August 2024
Paediatrics, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Bartter syndrome is a rare condition that affects how kidneys handle salt and can be passed down from parents to kids.
- A case was reported about an 18-month-old boy who was not growing well and had to drink a lot of water and pee a lot.
- The doctors figured out he had Bartter syndrome through tests, and he was given medicine to help him feel better, showing how important it is to look closely at kids with growth problems.
Recently, augmenting the pulsation of the internal cerebral vein (ICV) has been reported to be a predictor of premature intraventricular hemorrhage (IVH); however, prophylaxis for IVH has not yet been established. Venous pulsation is a marker of central venous pressure elevation and may be improved after heart failure treatment. Herein, we report two cases of low-birth-weight infants (29 weeks and 31 weeks of gestational age), who exhibited improvements in ICV pulsation with relief of hemodynamically significant patent ductus arteriosus (hs-PDA) following indomethacin administration.
View Article and Find Full Text PDFTwo cases of eosinophilic pustular folliculitis successfully treated with abrocitinib.
J Dermatol
December 2024
Dermatology Hospital of Southern Medical University, Guangzhou, China.
Article Synopsis
- Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin disease mainly involving eosinophils and can appear in both follicle areas and less commonly in follicle-free areas.
- This case study details two patients with difficult-to-treat EPF who had previous treatment failures with various standard therapies.
- Both patients responded positively to the medication abrocitinib, achieving complete remission in one week and four weeks, with no side effects reported, suggesting it could be a safe treatment option for EPF.
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