We studied the role of purinergic PX receptors in the body response to cooling. In experiments on rats, PX receptor antagonist PPADS was administered in different modes, which resulted in changes of different characteristics of the thermoregulatory response to cold. Iontophoresis of PX antagonist into the skin decreased the thermal thresholds of all thermoregulatory responses to cooling, which can attest to a modulating effect of PX receptors on peripheral thermosensitive afferents. Intraperitoneal administration of PX antagonist suppressed thermoregulatory activity of skeletal muscles (shivering) developing during cooling without changing the thresholds of thermoregulatory responses. The findings suggest that ATP and PX receptors play an important role in the formation of the response to cooling.
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