AI Article Synopsis
- - The text discusses the potential of using human pluripotent stem cells (hPSCs) to create organs and study human development and diseases.
- - It specifically focuses on human intestinal organoids (HIOs) as a way to explore small intestine development and related health issues.
- - A method for transplanting HIOs into immunocompromised mice is outlined, emphasizing key steps for successful integration and the implications for bioengineering human small intestine.
Article Abstract
The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases. Herein, we provide a method for orthotropic transplantation of HIOs in immunocompromised mice. This method highlights the specific steps to successful engraftment and provides insight into the study of bioengineered human small intestine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559894 | PMC |
| http://dx.doi.org/10.1007/978-1-4939-6949-4_17 | DOI Listing |
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