AI Article Synopsis
- The study explores the link between oxytocin levels and impulsivity in children with ADHD, aimed at improving understanding of this disorder.
- The research involved 40 ADHD patients and a control group of 40 healthy peers, using blood tests to measure serum oxytocin and the Barratt impulsivity scale-11 (BIS-11) for assessment.
- Results indicated that ADHD patients had higher impulsivity scores and lower oxytocin levels compared to controls, suggesting a negative correlation between oxytocin and impulsivity in ADHD, particularly affecting attention.
Article Abstract
Introduction: Here we aimed to determine the relationship between oxytocin levels and impulsivity, which is an important aspect at Attention Deficit Hyperactivity Disorder (ADHD) clinics.
Methods: The study population comprised 40 ADHD patients diagnosed based on the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version, without other psychiatric disorders and chronic diseases aged between 8 and 15 years. The control group comprised 40 healthy, age-matched, male children and adolescents who voluntarily participated in the study. Patients and controls filled the Barratt impulsivity scale-11 (BIS-11). Ten cubic centimeters of blood was collected at 8 am for determining serum oxytocin levels. ELISA kits were used to measure serum oxytocin levels in a biochemistry laboratory. The obtained data were evaluated using appropriate statistical methods.
Results: In this study, compared with the control group, the impulsivity scores were significantly higher and serum oxytocin levels were lower in the ADHD group (52.5±18.1 and 37.62±9.0, respectively, p<0.001). Serum oxytocin levels showed a negative correlation with impulsivity and attention subscale scores of BIS-11 in the ADHD group.
Conclusion: ADHD and impulsivity, which comprise an aspect of ADHD, may be associated with oxytocin. Serum oxytocin levels may contribute to inattention subtypes of impulsivity observed in ADHD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353033 | PMC |
| http://dx.doi.org/10.5152/npa.2015.10284 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy .
Neuro Endocrinol Lett
December 2024
Department of Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.
Objectives: We aimed to investigate the effect of hand therapy (HT) on oxytocin and oxytocin receptor expression in a chemotherapy-induced peripheral neuropathy (CIPN) model mouse.
Methods: CIPN model mouse was induced by intraperitoneal injection of paclitaxel (PTX; 4 mg/kg) on days 0, 2, 4 and 6 of the study. HT was performed on the CIPN mice once daily for 14 consecutive days, starting on day 8 after the PTX injection.
Physiological welfare indicators in wild cetaceans: Epidermal cortisol and oxytocin concentrations in stranded striped dolphins.
Comp Biochem Physiol A Mol Integr Physiol
December 2024
Department of Animal and Food Science, School of Veterinary Science, Universitat Autònoma de Barcelona, Bellaterra, Spain; Animal Welfare Education Centre (AWEC), School of Veterinary Science, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Anthropogenic pressures and climate change present growing challenges for cetaceans, as the combined effects of multiple stressors can jeopardize their welfare and survival. In this context, validating reliable individual welfare indicators is crucial for quantifying these impacts. This study aimed to validate a method for measuring cortisol and oxytocin from the epidermis of stranded striped dolphins (Stenella caeruleoalba) using enzyme immunoassays, while accounting for confounding factors such as epidermal layer and body location.
View Article and Find Full Text PDFJuvenile chronic social defeat stress reduces prosocial behavior in adult male mice.
Pharmacol Biochem Behav
December 2024
Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology (SZX2020013), Hebei Medical University, 050017, China. Electronic address:
Exposure to stress in early life can have a significant impact on individuals. However, the effects of early-life stress (ELS) on prosocial behavior remain unclear, as do the underlying mechanisms. In this study, ICR juvenile mice were subjected to juvenile chronic social defeat stress (jCSDS) between postnatal days 32 and 41, during which body weight changes were continuously monitored.
View Article and Find Full Text PDFEffects of cloprostenol and oxytocin on ultrasonographic changes of uterine horns in postpartum primiparous Hu sheep.
Anim Reprod Sci
January 2025
College of Animal Science and Technology, Shihezi University, Shihezi 832003, China. Electronic address:
This study aimed to evaluate the effects of exogenous hormones on postpartum ultrasonographic changes of uterine horn in Hu sheep. 90 nulliparous Hu sheep were divided into three groups according to the number of lambs. Each group was further randomly subdivided into three groups (n = 10), a control group (sodium chloride), a PG group (cloprostol), and a PG+OT group (cloprostol + oxytocin).
View Article and Find Full Text PDFThe roles of regulatory-compliant media and inflammatory/oxytocin priming selection in enhancing human mesenchymal stem/stromal cell immunomodulatory properties.
Sci Rep
November 2024
Department of Orthopaedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Osteoarthritis (OA) represents a significant global health burden without a known disease modifying agent thereby necessitating pursuit of innovative therapeutic approaches. The infrapatellar fat pad (IFP) serves as a reservoir of mesenchymal stem/stromal cells (MSC), and with adjacent synovium plays key roles in joint disease affecting local inflammatory responses. Therapeutically, IFP-MSC have garnered attention for their potential in OA treatment due to their immunomodulatory and regenerative properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!