AI Article Synopsis
- The study aimed to examine different T-cell subpopulations in the blood of rheumatoid arthritis patients who are either positive or negative for human parvovirus B19, along with healthy individuals.
- Blood samples from 115 RA patients and 47 healthy participants were analyzed using flow cytometry to measure levels of certain T-cell markers (CD4, CD8, CD25, and CD45RA).
- Results showed that patients with B19-positive RA had higher levels of regulatory T-cells compared to those who were B19-negative and healthy controls, suggesting a possible link to persistent viral infections.
Article Abstract
Aim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19) and -negative (B19) patients with rheumatoid arthritis (RA) and healthy persons.
Patients And Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19 Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4CD45RA, CD4CD45RA, CD8CD45RA, CD8CD45RA subsets were analyzed by flow cytometry.
Results: The percentage of CD25 and CD25 cells was increased on CD4CD45RA, CD4CD45RA T-cells and the percentage of CD25 cells was increased on CD8CD45RA, CD8CD45RA T-cells of B19 patients with RA in comparison with B19 patients and controls.
Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19 RA patients could cause down-regulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411743 | PMC |
| http://dx.doi.org/10.21873/invivo.11043 | DOI Listing |
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