Considerable effort goes into mitigating the impacts caused by invasive animals and prohibiting their establishment or expansion. In Australia, management of wild dogs (Canis lupus dingo and their hybrids) and their devastating impacts is reliant upon poison baiting. The recent release of baits containing the humane toxin para-aminopropiophenone (PAPP) offers potential improvements for control of wild dogs, but little is known about the environmental persistence of PAPP in manufactured baits that could be used to inform best practice guidelines. We investigated the degradation rate of PAPP wild dog baits (DOGABAIT™) under typical field usage and storage conditions in north-eastern Australia and calculated optimal deployment and withholding periods. The PAPP content of buried baits declines faster than surface-laid baits, but both presentations retained lethal doses to wild and domestic dogs for considerable periods (6-16 weeks). Domestic or working dogs should be suitably restrained or excluded from baited areas for extended periods, particularly under dry conditions, to minimise poisoning risk. The period of persistence of PAPP baits may provide opportunities to improve the duration or longer term efficacy of baiting campaigns, but care is needed to protect domestic and working dogs to ensure responsible and safe use.
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http://dx.doi.org/10.1007/s11356-017-8668-3 | DOI Listing |
Aust Vet J
January 2025
Melbourne Veterinary School, University of Melbourne, Werribee, Victoria, Australia.
Background: PAPP is widely used in Australia as a potent vertebrate bait, with potential for off-target ingestion and poisoning in domestic dogs. Whilst toxicosis and resulting methaemoglobinaemia is anecdotally known to occur, this is the first description in the literature. This study reports thirteen clinical cases of suspected Para-aminopropiophenone (PAPP) toxicity in dogs, with the aim of describing clinical presentation and current management of toxicosis in this species.
View Article and Find Full Text PDFPLoS One
March 2023
Manaaki Whenua Landcare Research, Lincoln, New Zealand.
Methaemoglobin (MetHb) forming compounds such as para-aminopropiophenone (PAPP) and sodium nitrite (NaNO2) have recently been adopted for the lethal control of a range of invasive carnivores and mustelids. Determining the relative hazard of these compounds to non-target bird species is an important component of ecological risks evaluation. Problematically, some potential non-target bird species may be as small as 10 g in body mass, thus placing limitations on blood volumes that can be routinely sampled.
View Article and Find Full Text PDFAnimals (Basel)
January 2023
Natural Resources Institute Finland (Luke), Production Systems, Halolantie 31 A, FI-71750 Maaninka, Finland.
Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming agent used for the lethal control of exotic carnivores and mustelids. To assess the sensitivity of Australian wildlife to PAPP we developed an in vivo assay that did not use death as an endpoint. Sub-lethal dose-response data were modelled to predict PAPP doses required to achieve an endpoint set at 80% MetHb (MetHb).
View Article and Find Full Text PDFAnimals (Basel)
January 2023
Manaaki Whenua Landcare Research, Lincoln 7608, New Zealand.
Para-aminopropiophenone (PAPP) is a methaemoglobin (MetHb) forming compound used for the lethal control of invasive carnivores and mustelids. By measuring the dose-dependent inhibition of O transport arising from the oxidation of haemoglobin (HbFe) to MetHb (HbFe), we determined the sensitivity of nine bird species to PAPP. A methaemoglobinaemia absorbance index (MAI) was validated in five common bird species to determine thresholds associated with a 99% probability of survival (ST) and a 50% probability of mortality (LT).
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
May 2019
Institute for Life Sciences and the Environment, University of Southern Queensland, Toowoomba, Queensland, 4350, Australia.
Lethal control remains an important approach to mitigating the impacts of predators on livestock and threatened fauna. This occurs in Australia, where wild dogs (Canis familiaris) and European red foxes (Vulpes vulpes) are commonly subjected to broad-scale poisoning programs. Ongoing refinement of lethal tools has led to the recent development of manufactured poison baits containing para-aminopropiophenone (PAPP).
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