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http://dx.doi.org/10.15698/mic2014.04.142 | DOI Listing |
BMC Genom Data
January 2025
School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 101E, Ottawa, Ontario, K1G 5Z3, Canada.
High intraocular pressure (IOP) is an important risk factor for glaucoma, which is influenced by genetic and environmental factors. However, the etiology of high IOP remains uncertain. Metabolites are compounds involved in metabolism which provide a link between the internal (genetic) and external environments.
View Article and Find Full Text PDFNature
January 2025
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites. Such modifications have been proposed to trigger the selective removal of chemically marked proteins; however, identifying modifications that are sufficient to induce protein degradation has remained challenging.
View Article and Find Full Text PDFFood Chem
January 2025
Engineering Laboratory for Industrial Microbiology Molecular Beeding of Anhui Province, College of Biological Food Engineering, Anhui Polytechnic University, 8 Middle Beijing Road, Wuhu 241000, Anhui Province, People's Republic of China. Electronic address:
The growth and metabolism of caproic acid - producing bacteria (CPBs) in the pit mud (PM) within the Huangshui (HS) are crucial for both the quality of Chinese Nongxiangxing Baijiu (NXXB) fermentation and the aging of the PM. Based on multi-database co-annotation and key affecting factors identification of CPBs, the growth and metabolites pattern of CPBs was studied through the pH-mediated PM-HS co-fermentation. CPBs in PM were mainly from Oscillospiraceae family.
View Article and Find Full Text PDFCurr Alzheimer Res
January 2025
Student's Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative condition with rising prevalence due to the aging global population. Existing methods for diagnosing AD are struggling to detect the condition in its earliest and most treatable stages. One early indicator of AD is a substantial decrease in the brain's glucose metabolism.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
February 2025
Aging and Metabolism Research Group, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea.
Background: Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growing interest in leveraging autophagy to mitigate muscle ageing effects.
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