AI Article Synopsis
- Charcot arthropathy is a severe complication of diabetic foot syndrome that often results in limb amputation, and early diagnosis and preventive care are crucial since there is no cure.
- Diagnosis is challenging due to the disease's unclear clinical symptoms and the absence of specific molecular markers for early detection.
- Recent research highlights the OPG-RANKL-RANK pathway's role in bone metabolism and identifies specific SNPs in the OPG gene, suggesting their potential use as markers for Charcot arthropathy and providing insights into the disease's molecular mechanisms.
Article Abstract
Charcot arthropathy is one of the most serious complications of diabetic foot syndrome that leads to amputation of the affected limb. Since there is no cure for Charcot arthropathy, early diagnosis and implementation preventive care are the best available treatment. However, diagnosis is hindered by obscure clinical picture of the disease and lack of molecular markers for its early detection. Results of recent research suggest that OPG-RANKL-RANK axis regulating bone metabolism can be associated with Charcot arthropathy and that SNPs in OPG gene are associated with the disease. Here we report the results of comprehensive analysis of ten SNPs in OPG, RANKL and RANK genes in 260 subjects divided into diabetes, neuropathy and Charcot arthropathy groups. Besides genotype analysis we performed linkage disequilibrium and hierarchical clustering to obtain information about correlation between SNPs. Our results show that OPG 245T/G (rs3134069) and OPG 1217C/T (rs3102734) polymorphisms co-occur in patients with Charcot arthropathy (r2 = 0.99). Moreover, hierarchical clustering revealed a characteristic profile of all SNPs in Charcot arthropathy and neuropathy, which is distinct from control group. Our results suggest that analysis of multiple SNPs can be used as potential marker of Charcot arthropathy and provide insight into possible molecular mechanisms of its development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428699 | PMC |
| http://dx.doi.org/10.1038/s41598-017-00563-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of Total Hip Arthroplasty Combined With Hip Braces for Hip Charcot Arthropathy.
Orthop Surg
December 2024
The First Clinical College, Jinan University & Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Objective: Charcot arthropathy is characterized by varying degrees of sensory loss and rapidly progressive joint destruction. Historically, limited studies indicated that Charcot arthropathy of the hip joint may be a contraindication for total hip arthroplasty (THA). Yet, some recent studies have shown that good clinical results and acceptable survival rate.
View Article and Find Full Text PDFTherapeutic role of Differential Target Multiplexed (DTM) spinal cord stimulation in painful diabetic neuropathy. Case report.
Pain Manag
December 2024
Endocrinology and Diabetes Unit, Bambino Gesù Childrens' Hospital, IRCCS, Rome, Italy.
Diabetic peripheral polyneuropathy (DPN) is the most common cause for diabetic foot complications, including diabetic ulcers, Charcot arthropathy, and lower limb amputations. Spinal Cord Stimulation (SCS) is a safe and effective treatment used for pain reduction in neuropathic/nociceptive pain conditions; the most common stimulation modalities used for the management of painful diabetic neuropathy were conventional paresthesia-based and high-frequency SCS, which stimulate the A beta fibers in the dorsal column of the spinal cord. Differential Target Multiplexed (DTM) SCS is a novel paresthesia-free stimulation technique targeting the supportive glial cells in the nervous system, modulating glial cells and neurons with a rebalance of their interactions.
View Article and Find Full Text PDFSurvey of Utilization of Weightbearing Computed Tomography Within AOFAS Membership.
Foot Ankle Spec
December 2024
Division of Orthopedic Foot and Ankle Surgery, Department of Orthopaedic Surgery, Duke University, Durham, North Carolina.
Background: Weightbearing computed tomography (WBCT) has been increasingly employed to evaluate and treat patients with varied pathologies such as progressive collapsing foot deformity (PCFD), posttraumatic deformity, hallux valgus, ankle arthritis, Charcot arthropathy, lisfranc, and syndesmosis injuries. However, little is known regarding its overall availability to foot and ankle providers and how it is being used in clinical practice. The goal of this study is to assess the utilization of WBCT among AOFAS members, identify the indications for use in clinical practice and potential barriers for implementation.
View Article and Find Full Text PDFDiagnosis and Management of Orthopaedic Conditions Associated With Hereditary Sensory Autonomic Neuropathies.
J Am Acad Orthop Surg
November 2024
From the Paley Orthopedic and Spine Institute, West Palm Beach, FL (Nugraha, Hariharan, Huser, and Feldman), and Department of Surgery, Florida Atlantic University School of Medicine (Hariharan and Feldman), Boca Raton, FL.
Hereditary sensory and autonomic neuropathies (HSANs) encompass a diverse group of inherited neuropathies characterized by notable sensory and autonomic involvement that affects musculoskeletal structures and systemic function. There are 8 recognized types of HSAN. The orthopaedic manifestations of HSAN are complex and diverse, including spinal deformity, Charcot arthropathy, osteomyelitis, fractures, osteonecrosis, osteoporosis, and skeletal deformities.
View Article and Find Full Text PDFFactors associated with the development of recurrent and contralateral Charcot neuroarthropathy in individuals with diabetes mellitus: A scoping review.
J Foot Ankle Res
December 2024
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia.
Introduction: Charcot neuroarthropathy (CN) can result in fractures and dislocations of the foot and ankle in individuals with diabetes and neuropathy, leading to ulceration, amputation and a poor quality of life. Additional episodes of acute CN can lead to extended periods of physical and psychosocial distress. The aim of this scoping review was to identify and synthesise the evidence relating to factors associated with the development of recurrent and contralateral Charcot neuroarthropathy (CN) in individuals with diabetes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!