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POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation.
J Gastrointest Cancer
June 2024
Department of Pathology, University of Szeged, Állomás U. 1, Szeged, 6725, Hungary.
Introduction: POLE mutant phenotype in colon adenocarcinomas represents a rare molecular subtype. These tumours are generally responsive to immune-checkpoint inhibition therapy and, therefore, are currently considered as a subtype with good prognosis. We hereby present the first detailed case presentation of a POLE mutant colon adenocarcinoma with useful microscopic features.
View Article and Find Full Text PDF[Multicentric Hungarian results of cabozantinib therapy in patients with metastatic kidney cancer based on real-world data].
Magy Onkol
March 2023
Urogenitális Tumorok és Klinikai Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.
The aim of our analysis was to evaluate the efficacy of cabozantinib in patients with metastatic renal cell carcinoma. Cabozantinib therapy initiated between 01/01/2019 and 31/12/2022 was evaluated based on a retrospective review of data from 14 renal centers in Hungary. The starting dose was 60 or 40 mg.
View Article and Find Full Text PDF[Not Available].
Magy Onkol
March 2022
Dél-pesti Centrumkórház Országos Hematológiai és Infektológiai Intézet, Budapest, Hungary.
The primary aim of AVACONT was to collect data in the course of routine oncological care from patients with metastatic colorectal cancer (mCRC) treated with bevacizumab supplemented fluoropyrimidine-based chemotherapy doublet in an open, multicentre, observational study in Hungary. Primary endpoint of the study was to determine progression-free survival (PFS). The Full Analysis Set (FAS) comprised 280 patients.
View Article and Find Full Text PDFAdenocarcinoma arising from a foregut cyst of the diaphragm: importance of multimodality treatment: a case report.
BMC Surg
December 2020
Department of Surgery, Faculty of Medicine, University of Szeged, Semmelweis str. 8, Szeged, 6725, Hungary.
Background: Benign foregut cysts usually develop in the thorax most of all in the mediastinum. Rare cases involving various abdominal organs, such as liver, stomach or pancreas have been previously published, mostly occurring in the retroperitoneum.
Case Presentation: We herein present an adenocarcinoma of a foregut cyst involving the left side of the diaphragm, left lower lobe of the lung, and left lobe of the liver, successfully removed through multivisceral resection.
Survival Benefits of Second-line Axitinib Versus Everolimus After First Line Sunitinib Treatment in Metastatic Renal Cell Carcinoma.
Pathol Oncol Res
October 2020
Department of Oncotherapy, University of Szeged, Korányi fasor 12, 6720, Szeged, Hungary.
Background: Targeted therapies significantly improve clinical outcomes among patients with metastatic renal cell carcinoma (mRCC). Several new agents have been approved for first- and second-line use. However, there is a lack of compelling evidence comparing sequencing strategies, and available comparative data regarding the real-world effectiveness of different therapeutic sequences are limited.
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