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http://dx.doi.org/10.1007/BF02252441 | DOI Listing |
Canine Med Genet
March 2021
Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
Background: Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds including the Rottweiler are associated with elevated osteosarcoma risk. However, these studies were often limited by selection bias and confounding factors, and have rarely offered insights into breed-associated protection for osteosarcoma.
View Article and Find Full Text PDFCan Vet J
September 2019
Veterinary Agri-Health Services Ltd., 201-151 East Lake Blvd. NE, Airdrie, Alberta T4A 2G1 (Homerosky, Johnsen, Jelinski); University of Calgary Faculty of Veterinary Medicine, TRW 2D01, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Steinmann, Matejka).
An outbreak of congenital diffuse hyperplastic goiter and chondrodystrophy occurred among springborn calves at an Angus-based cow-calf operation in southern Alberta. Although these diseases are observed globally in multiple species, reports of their occurrence concurrently are exceptionally rare. A nutritional cause is highly suspected as previous matings between the same sires and dams resulted in apparently normal calves.
View Article and Find Full Text PDFInt J Mol Sci
March 2017
Department of Biological Sciences, Boise State University, Boise, ID 83725, USA.
Chondrocytes of the growth plate undergo apoptosis during the process of endochondral ossification, as well as during the progression of osteoarthritis. Although the regulation of this process is not completely understood, alterations in the precisely orchestrated programmed cell death during development can have catastrophic results, as exemplified by several chondrodystrophies which are frequently accompanied by early onset osteoarthritis. Understanding the mechanisms that underlie chondrocyte apoptosis during endochondral ossification in the growth plate has the potential to impact the development of therapeutic applications for chondrodystrophies and associated early onset osteoarthritis.
View Article and Find Full Text PDFJ Anim Physiol Anim Nutr (Berl)
February 2016
Faculty of Veterinary Science, University of Sydney, Camperdown, NSW, Australia.
Congenital chondrodystrophy of unknown origin (CCUO) has been reported in beef cattle worldwide. A trace mineral deficiency in pregnant dams has been suggested as causing the deformities seen in CCUO calves. An extended outbreak of CCUO in Australia between 2002 and 2009 provided an opportunity to examine the pattern of trace mineral status in gestating cows and the effect of parenteral trace mineral supplementation on a herd at risk of CCUO calves.
View Article and Find Full Text PDFPan Afr Med J
September 2013
Faculté de Médecine, Université de Lubumbashi, 1825 Lubumbashi, Democratic Republic of Congo.
We describe the first Congolese case of Greenberg Skeletal Dysplasia. Were noted at birth a congenital hydrops, a chondrodystrophy, a severe hypoplastic face as well as an ulnar (postaxial) hexadactyly on all four limbs.
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