AI Article Synopsis
- Salvianolic acid B (Sal B) is a phenolic compound that shows promise in protecting against cerebral ischemia injury through its antioxidation and neuroprotective properties.
- Recent research indicates that Sal B may also help prevent steroid-induced osteonecrosis of the femoral head by improving histopathological scores, inhibiting osteoclast differentiation, and promoting the osteogenesis of mesenchymal stem cells in rat models.
- The treatment with Sal B affects specific proteins related to bone metabolism, suggesting it works by modulating PPARγ expression, which may provide a potential therapeutic approach for managing steroid-induced osteonecrosis.
Article Abstract
Salvianolic acid B (Sal B) is a water-soluble phenolic compound derived from . Recent studies show Sal B has a clear function of anti-cerebral ischemia injury, which is closely related to antioxidation, free radical scavenging, neuroprotection and the blood brain barrier. The aim of the present study was to verify whether Sal B prevents steroid-induced osteonecrosis of the femoral head and to investigate its underlying pharmacological mechanisms. Steroid-induced osteonecrosis rat models were established to evaluate the effects of Sal B on osteonecrotic changes and repair processes. The use of Sal B improved steroid-induced histopathological scores and inhibited osteoclast differentiation in rats. Notably, Sal B induced bone marrow-derived mesenchymal stem cells into osteogenesis. Moreover, Sal B treatment suppressed peroxisome proliferator-activated receptor (PPAR)γ and AP2 protein expression levels and increased runt-related transcription factor 2 and Collagen I protein expression levels in steroid-induced rats. osteocalcin and alkaline phosphatase content in steroid-induced rats was enhanced by treatment with Sal B. These results suggest that Sal B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats. The present pilot study provides a brief insight into the effect of Sal B on steroid-induced osteonecrosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348693 | PMC |
| http://dx.doi.org/10.3892/etm.2016.4008 | DOI Listing |
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