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From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair.
Mater Today Bio
February 2025
Discipline of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
Peripheral nerve repair (PNR) is a major healthcare challenge due to the limited regenerative capacity of the nervous system, often leading to severe functional impairments. While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). However, the inherently slow nerve growth rate (∼1 mm/day) and prolonged neuroinflammation, delay recovery even with the use of passive (no-conductive) NGCs, resulting in muscle atrophy and loss of locomotor function.
View Article and Find Full Text PDFRecent advances in nanomedicine design strategies for targeting subcellular structures.
iScience
January 2025
Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The current state of cancer treatment has encountered limitations, with each method having its own drawbacks. The emergence of nanotechnology in recent years has highlighted its potential in overcoming these limitations. Nanomedicine offers various drug delivery mechanisms, including passive, active, and endogenous targeting, with the advantage of modifiability and shapability.
View Article and Find Full Text PDFA POCIS-based approach for the monitoring of pharmaceuticals in wastewater treatment plants: Calibration and deployment challenges.
Environ Pollut
January 2025
Department of Analytical and Applied Chemistry, School of Engineering, IQS-Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain. Electronic address:
Article Synopsis
- The study investigates the use of Polar Organic Chemical Integrative Samplers (POCIS) as a more effective method for monitoring pharmaceutical residues in wastewater compared to traditional grab sampling.
- POCIS allows for continuous sampling over days or weeks, providing more representative data, though challenges remain in obtaining precise quantitative results due to calibration needs.
- The research successfully identifies and calibrates sampling rates for 49 pharmaceuticals in a wastewater treatment plant near Barcelona, yielding high concentrations of specific compounds, thus establishing a methodology for better environmental monitoring of pharmaceuticals.
Implantable Passive Sensors for Biomedical Applications.
Sensors (Basel)
December 2024
School of Electrical and Computer Engineering, National Technical University of Athens, 15772 Athens, Greece.
Article Synopsis
- Implantable sensors are becoming popular for localized and continuous monitoring in medical settings, allowing for early detection and timely interventions.
- There are two main types of implantable sensors: active, which have more advanced functionalities but require a power source, and passive, which don't need power and offer simpler, smaller designs.
- This review focuses on passive sensor technologies, discussing their materials, detection methods, clinical applications, advantages over active sensors, and important considerations for their packaging and compatibility with the human body.
Toward Large-Scale Photonic Chips Using Low-Anisotropy Thin-Film Lithium-Tantalate.
Adv Sci (Weinh)
January 2025
College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Photonic manipulation of large-capacity data with the advantages of high speed and low power consumption is a promising solution for explosive growth demands in the era of post-Moore. A well-developed lithium-niobate-on-insulator (LNOI) platform has been widely explored for high-performance electro-optic (EO) modulators to bridge electrical and optical signals. However, the photonic waveguides on the x-cut LNOI platform suffer serious polarization-mode conversion/coupling issues because of strong birefringence, making it hard to realize large-scale integration.
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