MicroRNAs Make a Difference in Cardiovascular Robustness.

Dev Cell

Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611, USA. Electronic address:

Published: March 2017

AI Article Synopsis

  • Invertebrate microRNAs (miRNAs) help reduce differences in development caused by changes in the environment and genetic factors.
  • Kasper et al. (2017) focus on zebrafish, showing how miRNAs play a role in stabilizing cardiovascular development during the embryo stage.
  • This research highlights the important relationship between miRNAs and the consistency (or robustness) of developmental processes.

Article Abstract

Invertebrate microRNAs (miRNAs) can suppress developmental variability that is caused by environmental and genetic variation. In this issue of Developmental Cell, Kasper et al. (2017) show that zebrafish miRNAs suppress variability in cardiovascular development during embryogenesis, providing insight into the conserved link between miRNAs and robustness.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831320PMC
http://dx.doi.org/10.1016/j.devcel.2017.03.009DOI Listing

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