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Unlabelled: Epilepsy, a neurological disorder affecting millions worldwide, poses great challenges in precisely delineating the epileptogenic zone - the brain region generating seizures - for effective treatment. High-frequency oscillations (HFOs) are emerging as promising biomarkers; however, the clinical utility is hindered by the difficulties in distinguishing pathological HFOs from non- epileptiform activities at single electrode and single patient resolution and understanding their dynamic role in epileptic networks. Here, we introduce an HFO-sequencing approach to analyze spontaneous HFOs traversing cortical regions in 40 drug-resistant epilepsy patients.
View Article and Find Full Text PDFSymptomatic Migraine with Prolonged Visual Aura and Unruptured Occipital Arteriovenous Malformation.
Acta Neurol Taiwan
December 2021
Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Neurology, Taipei Medical University, Taipei, Taiwan.
A 35 year-old woman had a two-year history of recurrent headache with clinical presentations of visual aura in her left visual field followed by right-sided throbbing headache. The patient suffered from a similar attack but her visual aura-like symptoms persisted for over 48 hours. The concurrent electroencephalogram demonstrated focal non-epileptiform rhythmic slow waves in the right occipital region.
View Article and Find Full Text PDFRecurrent non-epileptiform seizure-like phenomena secondary to propofol administration.
Can J Anaesth
July 2017
Division of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Newly diagnosed seizures in adults.
Neurosciences (Riyadh)
April 2003
Department of Neurology, King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia.
Objective: To study the clinical, electroencephalographic (EEG) and computed tomography (CT) profile in a hospital population of over 18-years adult patients with newly diagnosed recurrent seizures.
Methods: The clinical profiles obtained from history including detailed description of the seizures, examination, EEG and CT findings were recorded prospectively for all over-18 patients who were referred to the electrodiagnostic service at King Fahd Hospital of the University, Al-Khobar, Eastern Province, Kingdom of Saudi Arabia from January 1, 1996 to December 31, 1997. The data was entered into a standard database file and analyzed using a personal computer.
Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
Epilepsy Res
June 2002
Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892-1272, USA.
Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-discharge (AD) threshold; lengthening and spread of the AD; marked seizure stage progression culminating in full-blown tonic-clonic forelimb convulsions with rearing and falling; and evolution from triggered to spontaneous seizures. This evolving process concomitantly involves changes in the spatio-temporal expression of immediate early genes (IEGs), neurotrophic factors, and late effector genes (LEGs), and an associated changing pattern of effectiveness of different pharmacological interventions.
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