AI Article Synopsis
- Cells use different metabolic strategies during development to support growth, energy production, and tissue demands.
- Some metabolic states offer strict nutrient use, while others allow flexibility based on available nutrients as development progresses.
- The study highlights how understanding these metabolic programs, particularly using models like Drosophila egg development, can reveal mechanisms behind metabolic shifts during development.
Article Abstract
During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894399 | PMC |
| http://dx.doi.org/10.1016/j.gde.2017.03.002 | DOI Listing |
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