AI Article Synopsis
- Macrophage cholesterol efflux is crucial for reverse cholesterol transport, which maintains cholesterol balance and reduces atherosclerosis.* -
- Lipophagy, a newly identified process, enhances cholesterol efflux by breaking down lipid droplets in macrophages through autophagy and lysosomal activity.* -
- The review highlights recent findings on macrophage cholesterol efflux mechanisms and proposes lipophagy as a potential therapeutic target for treating atherosclerosis.*
Article Abstract
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368120 | PMC |
| http://dx.doi.org/10.3803/EnM.2017.32.1.41 | DOI Listing |
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