Purpose: Previously, we demonstrated enhanced adaptation after small bowel resection (SBR) in intestinal-specific retinoblastoma (Rb)-deficient mice along with elevated levels of insulin-like growth factor 2 (IGF2) expression within the villi. The purpose of this study was to verify that the insulin-like growth factor 1 receptor (IGF1R) plays a role in this phenomenon.
Methods: Inducible and intestinal specific Rb and IGF1R double knockout mice (iRb/IGF1R-IKO) (n=4) and Rb single knockout mice (iRb-IKO) (n=5) underwent 50% mid SBR. On post-operative day 28, mice were harvested, and structural adaptation was measured as changes in crypt depth and villus height. Rates of enterocyte proliferation were recorded. IGF2 expression within the remnant villi was measured via RT-PCR.
Results: Both iRb-IKO and iRb/IGF1R-IKO mice demonstrated enhanced adaptation with at least a 45% increase in both crypt depth and villus height in the proximal and distal remnant bowel. Both groups showed elevation of IGF2 expression in the remnant villi, but there were no differences between the two groups.
Conclusion: Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation in retinoblastoma-deficient mice. Our findings suggest that IGF2 signals for enhanced adaptation in cells outside of the epithelium. Further investigation is needed to study the IGF2/IGF1R signaling interaction within the mesenchyme.
Level Of Evidence: Animal study - not clinical.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466888 | PMC |
http://dx.doi.org/10.1016/j.jpedsurg.2017.03.030 | DOI Listing |
Alzheimers Dement
December 2024
Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Background: Cognitive impairment, a common aging-related pathology, is a risk factor for dementia. Echinacoside (ECH), derived from the traditional Chinese medicine Cistanche deserticola, shows anti-aging properties including anti-inflammation, oxidative stress reduction, and neuronal protection. Despite its benefits, the beneficial impact of ECH on age-related cognitive decline remains unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany.
Background: Given that the majority of people with dementia live in their homes in the community and are primarily cared for by informal caregivers, there is a growing interest in developing interventions suitable for this setting. Further, it is important to establish how music selections can differentially affect PwD. In this pilot trial, we thus compare two caregiver-delivered music listening MBIs with care-as-usual.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Augusta University, Augusta, GA, USA.
Background: Dementia compromises physical function, posing risks for falls. People living with dementia (PWD) have been historically excluded from intervention trials due to researchers' eligibility criteria. Exercise shows potential in enhancing physical function, but more evidence is needed.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Background: The global increase in dementia cases underscores the need for community-based services, particularly for older adults who spend significant time in their neighborhoods. This context profoundly influences cognitive function and quality of life, especially in those at high risk of cognitive impairment. Despite its importance, neighborhood cohesion has not been extensively studied in this group.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Venu Geriatric Institute, South Delhi, Delhi, India.
Background: This ethnographic inquiry offers a nuanced exploration into the lives of individuals contending with dementia in India, utilizing data from the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD). Recognizing dementia as a complex global health challenge, we delve into its unique manifestations within India's diverse regional and cultural landscape. While LASI-DAD provides valuable quantitative insights into prevalence and risk factors, our research complements these statistics by providing an in-depth understanding of the daily lives and lifestyles of those affected.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!