AI Article Synopsis
- * The tumor was identified as a large cell neuroendocrine carcinoma (LCNEC), which is less common compared to the typical small cell or carcinoid tumors that usually cause ectopic ACTH secretion.
- * Despite undergoing surgical removal and chemotherapy combined with radiation, the patient unfortunately died due to the aggressive progression of the LCNEC.
Article Abstract
We present an interesting case where a patient is presented with a droopy left eyelid (as part of Horner syndrome) and Cushingoid features which were a result of a Pancoast tumour (apical lung tumour in superior pulmonary sulcus) involving the left lung. This tumour was secreting ectopic adrenocorticotropic hormone (ACTH), a paraneoplastic endocrine phenomenon, which resulted in Cushing syndrome symptomatology. Though most ectopic ACTH-producing lung cancers are either small cell or carcinoid tumours, this was in fact a large cell neuroendocrine cancer (LCNEC). Patient underwent surgical resection and adjuvant/neoadjuvant chemotherapy with radiation; however, he succumbed to LCNEC given aggressive nature of the disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372167 | PMC |
| http://dx.doi.org/10.1136/bcr-2016-219156 | DOI Listing |
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