AI Article Synopsis
- Human herpesvirus 6B (HHV-6B) is primarily known for causing mild illness in infants, specifically exanthema subitum, but can lead to serious conditions like febrile seizures and encephalitis in some cases.
- Research found elevated levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid of patients with HHV-6B-related encephalitis compared to those with other types of febrile seizures.
- Laboratory studies showed that IL-1β and bFGF enhanced the expression of HHV-6B in infected brain cells, suggesting they play a role in promoting HHV-6B growth and the
Article Abstract
Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. In vitro, IL-1β and bFGF enhanced HHV-6B gene expression in infected U373 astrocytes during the initial and maintenance phases of infection, respectively. These findings indicated that IL-1β and bFGF contribute to HHV-6B growth and the onset of encephalitis.
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| http://dx.doi.org/10.1016/j.bbrc.2017.03.102 | DOI Listing |
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