AI Article Synopsis
- Primary cutaneous CD30 lymphoproliferative disorders include lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL), along with some indeterminate cases.
- LyP is a benign condition marked by recurrent red or violet papulonodules and has a 5-year survival rate of 100%, though it increases the risk of secondary malignancies.
- In contrast, pcALCL presents as a larger solitary nodule and has a high survival rate (over 95%) with appropriate therapies; aggressive chemotherapy is generally not recommended.
Article Abstract
Primary cutaneous CD30 lymphoproliferative disorders encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and indeterminate cases. LyP is a benign disorder characterized by recurrent crops of red or violaceous papulonodules. Patients with LyP are at an increased risk of a secondary malignancy. pcALCL is characterized by a solitary red to violaceous nodule or tumor larger than 20 mm. LyP is benign, is limited to the skin, and self-resolves, with a 5-year survival rate of 100%; pcALCL is limited to the skin and responsive to directed therapies, with a 5-year survival rate of over 95%. Aggressive chemotherapeutic regimens should be avoided.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776746 | PMC |
| http://dx.doi.org/10.1016/j.hoc.2016.11.006 | DOI Listing |
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