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| http://dx.doi.org/10.1038/cdd.2017.25 | DOI Listing |
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Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer.
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School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
The characteristics of neutrophils play a crucial role in defining the tumor inflammatory environment. However, the function of tumor-associated neutrophils (TANs) in tumor immunity and their response to immune checkpoint inhibitors (ICIs) remains incompletely understood. By analyzing single-cell RNA sequencing data from over 600,000 cells in gastric cancer (GSE163558 and GSE183904), colorectal cancer (GSE205506), and lung cancer (GSE207422), we identified neutrophil subsets in primary gastric cancer that are associated with the treatment response to ICIs.
View Article and Find Full Text PDFIdentification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
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Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.
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Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors.
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Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Background: Arsenic trioxide (ATO) is an anticancer agent for treating acute promyelocytic leukemia (APL). However, 5-10% of patients fail to respond, developing relapsed/refractory disease. The aim of this study was to identify potential new therapeutic approaches for ATO-unresponsive APL by targeting the anti-apoptotic genes that contribute to drug resistance.
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College of Veterinary Medicine, Southwest University, Chongqing 400715, PR China. Electronic address:
Pasteurella multocida (P. multocida) can cause infection in various animals, especially livestock and poultry, which can lead to substantial losses to the breeding industry. However, the pathogenesis of avian P.
View Article and Find Full Text PDFEPO modified MSCs protects SH-SY5Y cells against ischemia/hypoxia-induced apoptosis via REST-dependent epigenetic remodeling.
Sci Rep
October 2024
Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) is a condition causing brain injury from lack of oxygen and blood flow, mainly seen in newborns but can also affect adults; mesenchymal stem cell (MSC) therapies show promise in improving brain function after HIE.
- Research indicates that human umbilical cord MSCs (hUC-MSCs) express more erythropoietin (EPO) the longer they are exposed to hypoxia, and EPO can be secreted to aid in neuroprotection.
- The study employs techniques like flow cytometry, RNA sequencing, and CRISPR to explore how EPO-MSCs could reduce inflammation and apoptosis in brain cells after HIE, aiming
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