AI Article Synopsis
- Autophagy plays a critical role in various diseases such as infections, aging, neurodegenerative diseases, and cancer, and its regulation occurs at both the transcriptional and translational levels.
- Recent research highlights the importance of microRNAs in controlling the autophagy process, sparking interest in this area.
- This text provides an overview of how microRNAs regulate autophagy, specifically focusing on the mitophagy receptor NIX, and discusses methodologies for studying these interactions.
Article Abstract
The dysregulation of autophagy is implicated in many pathological disorders including infections, aging, neurodegenerative diseases, and cancer. Autophagy can be precisely controlled both transcriptionally and translationally. Accumulating evidences show that the autophagy response is regulated by microRNAs, which therefore becomes subject area of interest in recent years. Herein, we give a brief introduction of the recent advancement in the regulation of microRNA on autophagy, and then we focus on the microRNA regulation of the mitophagy receptor, NIX. Finally, we present the methodology on how to study it in detail.
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| http://dx.doi.org/10.1007/7651_2017_15 | DOI Listing |
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