AI Article Synopsis
- MSCs are crucial for cartilage tissue engineering but often lose their cartilage characteristics during long-term culture or implantation, leading to challenges in maintaining a stable phenotype.
- C-type natriuretic peptide (CNP) is linked to cartilage development and influences chondrocyte growth and differentiation.
- The hypothesis suggests that CNP may help stabilize the chondrocyte phenotype in MSCs-derived chondrocytes, potentially improving cartilage engineering outcomes.
Article Abstract
Mesenchymal stem cells (MSCs) play a critical role in cartilage tissue engineering. However, MSCs-derived chondrocytes or cartilage tissues are not stable and easily lose the cellular and cartilage phenotype during long-term culture or implantation . As a result, chondrocytes phenotypic instability can contribute to accelerated ossification. Thus, it is a big challenge to maintain their correct phenotype for engineering hyaline cartilage. As one member of the natriuretic peptide family, C-type natriuretic peptide (CNP) is found to correlate with the development of the cartilage, affect the chondrocytes proliferation and differentiation. Besides, based on its biological effects on protection of extracellular matrix of cartilage and inhibition of mineralization, we hypothesize that CNP may contribute to the stability of chondrocyte phenotype of MSCs-derived chondrocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340764 | PMC |
| http://dx.doi.org/10.3389/fphys.2017.00143 | DOI Listing |
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