AI Article Synopsis
- Recent interest has grown in using graphene oxide (GO) as a vaccine adjuvant, but its biocompatibility and effectiveness need to be improved through surface modifications.
- A new method to create chitosan (CS)-functionalized GO (GO-CS) has been developed, resulting in smaller size, positive charge, and better thermal stability.
- GO-CS shows enhanced immune response activation and potential as a safe nanoadjuvant for vaccines and immunotherapy due to the combined effects of GO and CS.
Article Abstract
The application of graphene oxide (GO) as a potential vaccine adjuvant has recently attracted considerable attention. However, appropriate surface functionalization of GO is crucial to improve its biocompatibility and enhance its adjuvant activity. In this study, we developed a simple method to prepare chitosan (CS)-functionalized GO (GO-CS) and further investigated its potential as a nanoadjuvant. Compared with GO, GO-CS possessed considerably smaller size, positive surface charge, and better thermal stability. The functionalization of GO with CS was effective in decreasing the non-specific protein adsorption and improving its biocompatibility. Furthermore, GO-CS significantly activated RAW264.7 cells and stimulated more cytokines for mediating cellular immune response, which was mainly due to the synergistic immunostimulatory effect of both GO and CS. GO-CS exhibits strong potential as a safe nanoadjuvant for vaccines and immunotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388161 | PMC |
| http://dx.doi.org/10.3390/nano7030059 | DOI Listing |
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