A novel cyclic ether, nesterenkoniane (), was isolated from the deep-sea-derived actinomycete MCCC 1K00610, together with 12 known compounds, including two macrolides (, ), two diketopiperazines (, ), two nucleosides (, ), two indoles (, ), three phenolics (-), and one butanol derivate (). Their structures were established mainly on detailed analysis of the NMR and MS spectroscopic data. All 13 compounds were tested for anti-allergic activities using immunoglobulin E (IgE) mediated rat mast RBL-2H3 cell model. Under the concentration of 20 μg/mL, exhibited moderate anti-allergic activity with inhibition rate of 9.86%, compared to that of 37.41% of the positive control, loratadine. While cyclo(d)-Pro-(d)-Leu () and indol-3-carbaldehyde () showed the most potent effects with the IC values of 69.95 and 57.12 μg/mL, respectively, which was comparable to that of loratadine (IC = 35.01 μg/mL). To the best of our knowledge, it is the first report on secondary metabolites from the genus of .
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