AI Article Synopsis
- The study looked at how obesity and nuclear β-catenin affect survival rates in patients with locally advanced rectal cancer.
- Obese patients had significantly fewer cancer recurrences and better disease-free survival compared to non-obese patients.
- Both obesity and nuclear β-catenin were found to be independent positive factors for improving disease-free survival in these patients receiving preoperative treatment.
Article Abstract
Background And Objective: We examined the prognostic value of obesity and nuclear β-catenin in patients with locally advanced rectal cancer.
Methods: We prospectively recruited a total of 98 eligible patients with locally advanced cancer for preoperative radiochemotherapy followed by total mesorectal excision. Patients' height and weight were reaorded before radiochemotherapy, and the immunohistochemical expression of nuclear β-catenin was analyzed. Disease-free survival (DFS) was analyzed using the Kaplan-Meier method and a Cox regression model was employed for the multivariate analysis.
Results: Obese patients were associated with a lower number of recurrences (3.6% vs. 34.3%, P = 0.001), and a higher DFS (95% vs. 53%; HR, 0.09; 95%CI, 0.01-0.64; P = 0.005) than non-obese patients. In the multivariate analysis, body mass index, nuclear β-catenin expression, and the absence of lymph node metastases showed a significant increase in DFS.
Conclusions: Obesity and nuclear β-catenin are independent favorable prognostic factors for DFS in locally advanced cancer treated with preoperative radiochemotherapy. J. Surg. Oncol. 2017;115:301-306. © 2017 Wiley Periodicals, Inc.
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| http://dx.doi.org/10.1002/jso.24494 | DOI Listing |
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