AI Article Synopsis
- This study compared the effects of isotonic fluids (0.9% saline in 5% dextrose) and hypotonic fluids (0.18% saline in 5% dextrose) on hyponatremia in children in a pediatric intensive care unit (PICU).
- Among 240 children, 16.7% in the hypotonic fluid group developed hyponatremia, while only 7.5% in the isotonic group did, indicating a significant difference (p = 0.029).
- The findings suggest that isotonic fluids may reduce the risk of hyponatremia and shorten PICU stay for children, supporting their use as
Article Abstract
Background: We aimed to compare the effect of two different intravenous fluid regimes on the incidence of hyponatremia in children.
Methods: Children 1 month to 18 years of age, admitted to pediatric intensive care unit (PICU) of a tertiary care medical college hospital were randomized to receive either isotonic fluid (0.9% saline in 5% dextrose) at the standard maintenance rate or hypotonic fluid (0.18% saline in 5% dextrose) at two-thirds of the standard maintenance rate.
Results: A total of 240 children were randomized (120 isotonic, 120 hypotonic). In all, 16.7% children in hypotonic group developed hyponatremia compared with 7.5% in isotonic group (p = 0.029). Duration of PICU stay was significantly more in Hypotonic group.
Conclusion: We conclude that use of 0.9% saline in 5% dextrose as maintenance fluid helps in reducing the incidence of hospital-acquired hyponatremia and duration of intensive care unit stay among children admitted to PICU.
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| http://dx.doi.org/10.1093/tropej/fmx012 | DOI Listing |
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