Background: The purpose of this study was to investigate the immediate response to RegentK (Regeneration-Therapy by Khalifa) of patients with an acute rupture of the anterior cruciate ligament (ACL), regarding the gait mechanics and functional tests, in comparison to norm data.
Patients And Methods: 9 male patients with an acute unilateral ACL rupture underwent an orthopedic exam and gait analysis immediately before and after the 1-h RegentK treatment; the results were compared to norm data of 10 healthy participants matched with the RegentK group for age and body mass index. An infrared camera system collected kinematic gait data on the injured limb; the gait kinetics were recorded with 2 force plates.
Results: Immediately after the treatment, significant improvements with regard to limping, the quadriceps knee force, and the passive knee range of motion (ROM) occurred. The gait characteristics showed a significantly increased gait velocity (+0.17 m/s), step frequency (+8 steps/min), and injured-limb step length (+5 cm). The faster gait velocity involved increased sagittal ankle and hip ROM, increased maximal vertical ground reaction forces, internal ankle plantar flexion and hip flexion moments.
Conclusions: RegentK seems to immediately affect functional parameters such as passive knee joint motion and quadriceps strength and seems to enable patients to walk more dynamically, generally expressed through an increased walking speed.
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http://dx.doi.org/10.1159/000464414 | DOI Listing |
Background: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted.
Methods: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery.
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Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Early neurological deterioration (END) is associated with a poor prognosis in acute ischemic stroke (AIS). Effectively lowering low-density lipoprotein cholesterol (LDL-C) can improve the stability of atherosclerotic plaque and reduce post-stroke inflammation, which may be an effective means to lower the incidence of END. The objective of this study was to determine the preventive effects of evolocumab on END in patients with non-cardiogenic AIS.
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January 2025
Faculty of Medicine, Department of Emergency Medicine, Akdeniz University, Antalya, Turkey.
Patients presenting with suspected acute coronary syndrome (ACS) in the emergency department (ED) require rapid and accurate electrocardiographic (ECG) evaluation. This study aims to assess conventional ECG markers for diagnosing non-ST-elevation ACS (NSTE-ACS) in patients with chest discomfort and right bundle branch block (RBBB). A nested case-control design was employed to compare patients with RBBB admitted to the ED for suspected cardiac ischemia, focusing on those who developed NSTE-ACS versus those who did not.
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January 2025
The Queen's Medical Center, 1301 Punchbowl Street, QET 4M, Honolulu, Hawai'i, 96813, USA.
High flow nasal cannula (HFNC) can reduce the need for intubation in patients with coronavirus disease-19 (COVID-19) pneumonia induced acute hypoxemic respiratory failure (AHRF), but predictors of HFNC success could be characterized better. C-reactive protein (CRP) and D-dimer are associated with COVID-19 severity and progression. However, no one has evaluated the use of serial CRP and D-dimer ratios to predict HFNC success.
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January 2025
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.
Aberrant large-scale resting-state functional connectivity (rsFC) has been frequently documented in ischemic stroke. However, it remains unclear about the altered patterns of within- and across-network connectivity. The purpose of this meta-analysis was to identify the altered rsFC in patients with ischemic stroke relative to healthy controls, as well as to reveal longitudinal changes of network dysfunctions across acute, subacute, and chronic phases.
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