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Modulating gene expression as a strategy to investigate thyroid cancer biology.
Arch Endocrinol Metab
January 2025
Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de Biologia Celular e do Desenvolvimento São PauloSP Brasil Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.
Modulating the expression of a coding or noncoding gene is a key tool in scientific research. This strategy has evolved methodologically due to advances in cloning approaches, modeling/algorithms in short hairpin RNA (shRNA) design for knockdown efficiency, and biochemical modifications in RNA synthesis, among other developments. Overall, these modifications have improved the ways to either reduce or induce the expression of a given gene with efficiency and facility for implementation in the lab.
View Article and Find Full Text PDFRisk Factors and Predictors for Persistent Dyspnea Post-COVID-19: A Systematic Review.
Clin Nurs Res
January 2025
University of South Florida, Tampa, USA.
The most frequently reported post-coronavirus disease of 2019 (COVID-19) symptoms include shortness of breath, fatigue, and cognitive disturbances, with reports of persistent dyspnea ranging between 26% and 41%. There is an urgent need to understand the risk factors and predictors for persistent COVID-19 dyspnea in individuals at all levels of COVID-19 illness severity, to enable the implementation of targeted interventions for those likely to be most affected with persistent dyspnea. Thus, the purpose of this systematic review is to explore the risk factors and predictors that are associated with persistent dyspnea in the post-COVID-19 population.
View Article and Find Full Text PDFDoes drug dispensing influence patients' medication knowledge and medication adherence? A systematic review and meta-analysis.
BMC Health Serv Res
January 2025
Laboratory of Innovation for Healthcare (Linc), Postgraduate Program in Pharmaceutical Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil.
Background: Inadequate medication knowledge and medication nonadherence by patients are considered an issue in healthcare, as they can lead to negative outcomes, such as therapeutic failures and hospitalization. Even though drug dispensing, which has pharmacist counseling as a core element, is a service traditionally performed by pharmacists, there is still no evidence about the influence of this service on these health outcomes.
Objective: To evaluate the influence of drug dispensing on patients' medication knowledge and medication adherence.
Childhood BMI trajectories and sociodemographic factors in an Italian pediatric population.
Sci Rep
January 2025
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco- Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Childhood obesity is a growing global concern due to its long-term health consequences. Yet, more research relying on multiple time-point BMI measurements is warranted to gain further insight into obesity's temporal trends. We aimed to identify BMI trajectories in children aged 2-10 years and evaluate their association with sociodemographic factors.
View Article and Find Full Text PDFSingle-Session Interventions for Mental Health Problems and Service Engagement: Umbrella Review of Systematic Reviews and Meta-Analyses.
Annu Rev Clin Psychol
January 2025
3Department of Psychology, Stony Brook University, Stony Brook, New York, USA.
Most people with mental health needs cannot access treatment; among those who do, many access services only once. Accordingly, single-session interventions (SSIs) may help bridge the treatment gap. We conducted the first umbrella review synthesizing research on SSIs for mental health problems and service engagement in youth and adults.
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