AI Article Synopsis
- - The study aimed to explore the link between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels among middle-aged and elderly Chinese women, using a population survey from 2014 in Luzhou, China, involving 2,486 participants aged over 40.
- - Results showed that hyperuricemia prevalence was 25.1% in the population, with higher rates associated with increasing GGT levels; participants in the highest GGT quartile had more than double the odds of elevated uric acid compared to those in the lowest quartile.
- - The findings conclude that there is a significant association between serum GGT levels and hyperuricemia in this demographic, highlighting the
Article Abstract
Objective: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females.
Methods: A cross-sectional population survey was performed in Luzhou, China (2014). Questionnaires, physical examinations and biochemical tests were conducted. Finally, we included 2486 females who were > 40 years old as participants. Multiple linear regression analysis was used to estimate the association of serum acid levels and other variables. Serum GGT levels were divided into four groups using the 25th, 50th and 75th percentiles as cut-off points. Finally, binary logistic regression analysis was used to investigate the association of different serum GGT quartiles with the risk of hyperuricemia.
Results: The prevalence of hyperuricemia was 25.1% in the studied population and gradually increased across the serum GGT quartiles (P < 0.05). Binary logistic regression analysis showed that compared with subjects in the lowest quartile of serum GGT levels, the adjusted odds ratio (ORs) for uric acid in the highest quartile was 2.34 (95% confidence interval (CI), 1.68-3.28, P < 0.001),after corrections for TG, TC, HDL-C, LDL-C, creatinine (CR), GGT, AST, ALT, fasting plasma glucose (FPG), postprandial 2-h plasma glucose, hemoglobin A1c(HbA1c), age, BMI, SBP, DBP, waist-to-hip ratio and neck circumference (NC).
Conclusions: The serum GGT level is associated with hyperuricemia in middle-aged and elderly Chinese females.
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| http://dx.doi.org/10.1080/07435800.2017.1300809 | DOI Listing |
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