A new 1,8-naphthalimide-based fluorescent probe for the detection of diethyl cyanophosphonate, a very common nerve agent simulant, is designed, synthesized, and characterized fully. The probe shows around 50-fold enhancement of fluorescence intensity over other nerve agent simulants. Importantly, the probe is able to work under aqueous conditions in a wide pH range. Two reactive groups, the oxime and the phenol, allow a dual emission with different kinetic reactions. The reaction of diethyl cyanophosphonate with the oxime group occurs in advance; the resulting time response of the fluorescence enhancement is observed within approximately 30 s. After the oxime reaction, then phenol also undergoes a substitution reaction with diethyl cyanophosphonate, resulting in a blue emission. The real application of this new probe is demonstrated through the use of silica plate assays for the detection of diethyl cyanophosphonate in both gas and liquid phases through dual emission channels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201700975 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic Acid-Base Action Leads to Ultrafast Decontamination of Nerve and Blister Agents by OH Intercalated Zr-Doped MgAl-LDH under Ambient Conditions.
Adv Mater
December 2024
Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P. R. China.
Developing materials capable of rapidly decontaminating nerve and blister agents directly under ambient conditions are crucial for practical applications. In this work, MgAl Zr-LDH with different Zr doping contents and corresponding OH intercalated materials MgAl Zr-LDH-OH are synthesized. First, they are used for the decontamination of nerve agents under ambient conditions, showing that increasing the Zr doping amount accelerates the decontamination rate of diethyl cyanophosphonate (DECP) and soman (GD), with the half-life of DECP and GD being 3-5 times shorter with MgAlZr-LDH (the highest Zr doping content) compared to MgAl-LDH.
View Article and Find Full Text PDFReal-time, specific, and label-free transistor-based sensing of organophosphates in liquid.
Environ Res
December 2024
School of Electrical and Computer Engineering, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel; The Ilse-Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, POB 653, Beer-Sheva, 8410501, Israel. Electronic address:
Article Synopsis
- Organophosphates (OP) are harmful chemicals used in agriculture and warfare, creating a need for effective detection methods that work quickly and are cost-effective, especially for detecting contamination in liquid samples.
- Current detection methods are only useful in the short term and fail to address long-term contamination risks, highlighting the need for real-time monitoring of OPs in water and soil.
- This study introduces a transistor-based sensor called MNChem, capable of ultra-sensitive, quantitative detection of diethyl cyanophosphonate (DCNP) in small liquid samples, achieving a detection limit of 100 fg/mL and a wide dynamic range, suggesting it’s suitable for on-site environmental analysis.*
Water-recyclable and reusable fluorescent sensors for nerve gas mimetic detection.
Analyst
September 2024
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research Raebareli, Transit campus Lucknow, Uttar Pradesh, India.
Herein, the serendipitous discovery of two water-recyclable and reusable fluorescent sensors IMPC (cyan-blue-cyan) and IMPC-OH (green-blue-green) is reported for sensing nerve agent simulants diethylcyanophosphonate and diethylchlorophosphate, respectively, with high sensitivity, short response time, and low detection limits. The unique features of these probes are their regeneration with the addition of a green and cheap solvent, namely water in CHCl, and ease of fabrication into a portable paper-strip system that can also be regenerated. Various spectroscopic studies were employed to understand the mechanism of sensing and regeneration of both probes; the results reveal that water plays a critical role in the hydrolysis of the adduct formed with DCNP and DCP, which enables the retrieval of the probe with its original fluorescence.
View Article and Find Full Text PDFHighly specific and sensitive chromo-fluorogenic detection of sarin, tabun, and mustard gas stimulants: a multianalyte recognition approach.
Photochem Photobiol Sci
April 2024
Department of Chemistry, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, 734013, India.
Nerve agents are the most notorious substances, which can be fatal to an individual because they block the activity of acetylcholinesterase. Fighting against unpredictable terrorist assaults and wars requires the simple and quick detection of chemical warfare agent vapor. In the present contribution, we have introduced a rhodamine-based chemosensor, BDHA, for the detection of nerve gas-mimicking agents diethylchlorophosphate (DCP) and diethylcyanophosphonate (DCNP) and mustard gas-mimicking agent 2-chloroethyl ethyl sulfide (CEES), both in the liquid and vapor phase.
View Article and Find Full Text PDFConstruction of covalent organic framework nanozymes with photo-enhanced hydrolase activities for colorimetric sensing of organophosphorus nerve agents.
Anal Chim Acta
October 2023
School of Chemistry and Material Science, East China University of Technology (ECUT), Nanchang, 330013, China; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China. Electronic address:
Construction of covalent organic frameworks (COFs)-based nanozymes is of great importance for the extensive applications in catalysis and sensing fields. In this work, a two-dimensional COF (DAFB-DCTP COF) was fabricated via Knoevenagel condensation reaction. The integration of catalytically active sites of pyridine groups into the donor-acceptor (D-A) conjugated skeleton endows DAFB-DCTP COF with both hydrolytic and photosensitive properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!