AI Article Synopsis
- The concept of pure neuroendocrine breast tumors, first defined by Sapino et al., includes three sub-types: solid, small cell/oat cell, and large cell neuroendocrine carcinomas.
- To diagnose these tumors, over 50% of the tumor cells must show neuroendocrine differentiation, and it's crucial to rule out metastatic neuroendocrine carcinoma during diagnosis.
- The article discusses a patient who was initially misdiagnosed with ductal carcinoma in situ, highlighting the challenges in differentiating solid neuroendocrine carcinomas from ductal carcinoma due to their similar morphological features.
Article Abstract
The concept of pure neuroendocrine breast tumors was initially defined by Sapino et al. There are three sub-types of these tumors: solid, small cell/oat cell, and large cell neuroendocrine carcinomas. To diagnose neuroendocrine tumors, more than half of the tumor cells must have neuroendocrine differentiation. The possibility of metastatic neuroendocrine carcinoma must always be excluded in the differential diagnosis. In addition, it should be considered that solid neuroendocrine (NE) carcinomas can be confused with ductal carcinoma in situ due to their similar morphologic appearance. In this article, a patient with primary solid neuroendocrine breast cancer who had been diagnosed with ductal carcinoma in situ at another center was presented along with morphological and immunohistochemical features.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351469 | PMC |
| http://dx.doi.org/10.5152/tjbh.2014.1725 | DOI Listing |
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