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Effects of Sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) Receptor Hypofunction Induced by MK801: In Vivo Calcium Imaging in the CA1 Region of the Dorsal Hippocampus.
Brain Sci
November 2024
Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the negative and cognitive symptoms of schizophrenia. The aims of the present study were to observe the effects of sarcosine on neuronal activity in the dorsal CA1 (dCA1) hippocampal neurons within an NMDA receptor hypofunction model induced by MK801.
View Article and Find Full Text PDFActivation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice.
Acta Pharmacol Sin
September 2024
First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 435000, China.
Palmitoyl-protein thioesterase 1 (PPT1) is a lysosomal depalmitoylation enzyme that mediates protein posttranslational modifications. Loss-of-function mutation of PPT1 causes a failure of the lysosomal degradation of palmitoylated proteins and results in a congenital disease characterized by progressive neuronal degeneration referred to as infantile neuronal ceroid lipofuscinosis (INCL). A mouse knock-in model of PPT1 (PPT1-KI) was established by introducing the R151X mutation into exon 5 of the PPT1 gene, which exhibited INCL-like pathological lesions.
View Article and Find Full Text PDFInterplay of MeCP2/REST/Synaptophysin-BDNF and intranasal oxytocin influence on Aβ-induced memory and cognitive impairments.
Behav Brain Res
January 2025
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:
Article Synopsis
- Alzheimer's disease is associated with Aβ accumulation, tau hyperphosphorylation, neuroinflammation, and decreased neurotrophic factors, which impair memory and learning.
- The study involved administering Aβ to rats and then treating them with intranasal oxytocin to assess its effects on memory, neurogenesis, and synaptic plasticity.
- Results showed that intranasal oxytocin significantly enhanced spatial and working memory while increasing key factors related to synaptic plasticity, neurogenesis, and histone acetylation, suggesting potential therapeutic benefits for Alzheimer's disease.
Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.
J Neurosci
August 2024
Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China
The anterior cingulate cortex (ACC) is a key cortical region for pain perception and emotion. Different forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), have been reported in the ACC. Synaptic tagging of LTP plays an important role in hippocampus-related associative memory.
View Article and Find Full Text PDFUHPLC-MS/MS combined with microdialysis for simultaneous determination of nicotine and neurotransmitter metabolites in the rat hippocampal brain region: application to pharmacokinetic and pharmacodynamic study.
Anal Methods
June 2024
China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou, 450001, China.
Article Synopsis
- * The mechanisms behind how nicotine is processed in the hippocampus are still unclear, prompting the development of a new method that allows for the simultaneous measurement of several neurotransmitters, nicotine, and its metabolites.
- * Findings from this study indicate that nicotine and its metabolites behave differently in the hippocampus of certain groups, with nicotine being absorbed faster but eliminated slower, while also increasing the release of important neurotransmitters like dopamine and serotonin.
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