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| http://dx.doi.org/10.1136/bcr-2017-219463 | DOI Listing |
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Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro.
View Article and Find Full Text PDFGestational trophoblastic disease: STR genotyping for precision diagnosis.
Expert Rev Mol Diagn
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Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Introduction: Gestational trophoblastic disease (GTD) encompasses a constellation of rare to common gynecologic conditions stemming from aberrant gestations with distinct genetic backgrounds and variable degrees of trophoblast proliferation of either neoplastic or non-neoplastic nature. GTD is categorized into hydatidiform moles and gestational trophoblastic neoplasms, and their clinical outcomes vary widely across different subtypes. Prompt and accurate diagnosis plays a pivotal role in the effective management and prognostication of patients.
View Article and Find Full Text PDFMSH6-proficient crypt foci in MSH6 constitutional mismatch repair deficiency: reversion of a frameshifted coding microsatellite to its wild-type sequence.
Fam Cancer
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Colorectal Cancer Research Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
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- The discovery of "mismatch repair proficient (MMRp)-crypt foci" in a patient with constitutional MMR deficiency presents new insights into tumor development in Lynch syndrome (LS).
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Schwannosis in the brain of a neonatal calf.
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Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY, USA.
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November 2024
Department of Pathology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China. Electronic address:
Objective: U2AF homology motif kinase 1 (UHMK1) is a newly discovered molecule that may have multiple functions. Recent studies have revealed that UHMK1 had aberrant expression in many tumors and was associated with tumor progression. However, UHMK1 was rarely reported in oral squamous cell carcinoma (OSCC).
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